Malvern Zetasizer Ultra - Status: Available

  • Current Status: Available
  • Use Rates:
    • External Academic & Government: $52.50/Hour
    • External Affiliated Commercial/Industrial: $127.50/Hour
    • External Commercial/Industrial: $170.00/Hour
    • External International Academic: $70.00/Hour
    • Internal Standard: $35.00/Hour
  • Building: NANO (0070)
  • Room: Particle Analysis 4 (239)
  • In Cleanroom: No
  • Main Contact: Gary Scheiffele
The Zetasizer Ultra is the world’s most capable combined DLS and ELS system, incorporating Non-Invasive Back Scatter (NIBS®) and, uniquely, Multi-Angle Dynamic Light Scattering (MADLS) technology for the measurement of particle and molecular size. NIBS provides the versatility and sensitivity to measure over a wide concentration range, while MADLS permits a higher resolution view into your sample’s size distribution for those critical measurements.

An extension to MADLS affords the ability to analyze particle concentration of monodisperse samples below 500 nm. The measurement of particle concentration is calibration-free, suitable for a wide range of materials, requires no or little dilution, and is quick to use – all of which make it ideal as a screening technique. This is a unique capability of the Zetasizer Ultra which can even be applied to samples such as viruses and VLPs, which were previously very challenging to measure.

The Zetasizer Ultra also provides the highest sensitivity zeta potential and electrophoretic mobility measurements using M3-PALS technology. For zeta potential measurements the instrument requires affordable disposable folded capillary cells. The capillary cells enable measurements in extremely low volumes, without direct sample-electrode contact using the Malvern's patented diffusion barrier method and avoids sample cross-contamination. The information provided by these measurements is an excellent indicator of sample stability and/or propensity to aggregate.

The addition of Constant Current Mode for measuring electrophoretic mobility and zeta potential in high conductivity media reduces errors that can be associated with electrode polarization at higher ion concentrations. Latest Status Log EntryJan 21, 2020 - User Note: Dip cell has some black deposits near the electrodes. I tried to remove it using kim wipes and isopropanol but they seem to be stuck pretty strong. Perhaps acid clean will help?

Measurement

  • Particle size
  • Zeta potential
  • Molecular size
  • Particle concentration

Particle size range

  • 0.3nm to 10µm

Technology

  • Dynamic Light Scattering